Antagonism by pivagabine of stress-induced changes in GABAA receptor function and corticotropin-releasing factor concentrations in rat brain

@article{Serra1999AntagonismBP,
  title={Antagonism by pivagabine of stress-induced changes in GABAA receptor function and corticotropin-releasing factor concentrations in rat brain},
  author={M. Serra and A. Concas and M. Mostallino and M. Chessa and M. Stomati and F. Petraglia and A. Genazzani and G. Biggio},
  journal={Psychoneuroendocrinology},
  year={1999},
  volume={24},
  pages={269-284}
}
Pivagabine [4-(2.2-dimethyl-l-oxopropylamino) butanoic acid] (PVG) is a hydrophobic 4-aminobutyric acid derivative with neuromodulatory activity. The effects of subchronic treatment with PVG on stress-induced changes both on brain concentrations of corticotropin-releasing factor (CRF) and neurosteroids and on the function of the gamma-aminobutyric acid type A (GABAA) receptor complex were investigated in male rats. Subchronic treatment with PVG (100-200 mg/kg, i.p.) resulted in a dose-dependent… Expand
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