Antagonism by idazoxan at low dose but not high dose, of the natriuretic action of moxonidine.

@article{Allan1996AntagonismBI,
  title={Antagonism by idazoxan at low dose but not high dose, of the natriuretic action of moxonidine.},
  author={D R Allan and S. Brian Penner and Donald D. Smyth},
  journal={British journal of pharmacology},
  year={1996},
  volume={117 1},
  pages={29-34}
}
1. Recent studies concerning the imidazoline receptor have utilized idazoxan as a specific imidazoline receptor antagonist. The aim of the present study was to describe the in vivo effects of various doses of idazoxan on renal function, in the presence and absence of moxonidine, an I1 imidazoline receptor agonist. 2. In anaesthetized, unilaterally nephrectomized (7 to 10 days) Sprague Dawley rats, an intrarenal infusion of moxonidine (3 nmol kg-1 min-1) increased urine flow rate, sodium… CONTINUE READING

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