Antagonism between the HIV-1 reverse-transcriptase mutation K65R and thymidine-analogue mutations at the genomic level.

@article{Parikh2006AntagonismBT,
  title={Antagonism between the HIV-1 reverse-transcriptase mutation K65R and thymidine-analogue mutations at the genomic level.},
  author={Urvi M Parikh and Douglas C Barnas and Hawazin Faruki and John W Mellors},
  journal={The Journal of infectious diseases},
  year={2006},
  volume={194 5},
  pages={
          651-60
        }
}
Prior virologic and biochemical studies have shown phenotypic antagonism between K65R and multiple thymidine-analogue mutations (TAMs) in site-directed mutants tested in vitro. We hypothesized, on the basis of this observed antagonism, that K65R and T215Y/F with multiple TAMs would not be selected on the same human immunodeficiency virus type 1 genome in vivo. We searched a large database of patient genotypes (n=59,262) for the frequency of K65R in combination with >or=3 TAMs as determined by… CONTINUE READING

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