Antagonism between retinoic acid and fibroblast growth factor signaling during limb development.

@article{Cunningham2013AntagonismBR,
  title={Antagonism between retinoic acid and fibroblast growth factor signaling during limb development.},
  author={Thomas J. Cunningham and Xianling Zhao and Lisa L Sandell and Sylvia M. Evans and Paul A Trainor and Gregg Duester},
  journal={Cell reports},
  year={2013},
  volume={3 5},
  pages={1503-11}
}
The vitamin A metabolite retinoic acid (RA) provides patterning information during vertebrate embryogenesis, but the mechanism through which RA influences limb development is unclear. During patterning of the limb proximodistal axis (upper limb to digits), avian studies suggest that a proximal RA signal generated in the trunk antagonizes a distal fibroblast growth factor (FGF) signal. However, mouse and zebrafish genetic studies suggest that loss of RA suppresses forelimb initiation. Here… CONTINUE READING

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