Antagonism between pyracetam and proline in their effect on memory


Despite extensive clinical use of substances with nootropic activity the mechanism of their action is still largely unexplained. This applies above all to pyracetam, whose ability to accelerate recovery of memory functions when disturbed by harmful influences, and to increase resistance to hypoxia [i, ii] has not yet been sufficiently explained. There is now no doubt about the important role of mediator amino acids in realization of the effect of various neurotropic substances. In an attempt to analyze the mechanism of action of pyracetam, our attention was drawn to the amino acid proline, the only mediator amino acid which possesses some degree of structural similarity with the cyclic part of the pyracetam molecule.

DOI: 10.1007/BF00799073

2 Figures and Tables

Cite this paper

@article{Ostrovskaya2004AntagonismBP, title={Antagonism between pyracetam and proline in their effect on memory}, author={Rita U Ostrovskaya and Sergey S Trofimov and N. M. Tsybina and Tatyana A. Gudasheva and A. P. Skoldinov and V. V. Zakusov}, journal={Bulletin of Experimental Biology and Medicine}, year={2004}, volume={99}, pages={306-309} }