Antagonism between camptothecin and topoisomerase II-directed chemotherapeutic agents in a human leukemia cell line.

@article{Kaufmann1991AntagonismBC,
  title={Antagonism between camptothecin and topoisomerase II-directed chemotherapeutic agents in a human leukemia cell line.},
  author={Scott H. Kaufmann},
  journal={Cancer research},
  year={1991},
  volume={51 4},
  pages={
          1129-36
        }
}
To search for possible synergy between topoisomerase (topo) II-directed chemotherapeutic agents and topo I-directed agents, IL-60 human progranulocytic leukemia cells were incubated with etoposide in the absence or presence of camptothecin (CPT). Treatment of HL-60 cells for 1 h with 15-20 microM etoposide resulted in the death of 99-99.9% of the cells as assessed by colony formation in soft agar. Unexpectedly, simultaneous incubation with 1 microM CPT increased the survival of etoposide… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 62 CITATIONS

Similar Papers

Loading similar papers…