Antacids and gastric mucosal protection.

@article{Domschke1986AntacidsAG,
  title={Antacids and gastric mucosal protection.},
  author={W. Domschke and J. Hagel and H. Ruppin and B. Kaduk},
  journal={Scandinavian journal of gastroenterology. Supplement},
  year={1986},
  volume={125},
  pages={
          144-50
        }
}
Aluminum hydroxide-containing antacids have a protective effect on the stomach in that they prevent grossly visible mucosal necrosis and hemorrhages produced by noxious agents, such as aspirin or absolute ethanol. Histologically, this protective effect is mainly confined to the tissue located deep in the gastric mucosa, essentially comprising gastric glands, while the damage to the surface epithelium is not significantly lessened. Accordingly, integrity parameters of the superficial epithelial… Expand
Antacids: new perspectives in cytoprotection.
TLDR
Antacids have advantages over the H2 blockers in protecting the gastric mucosa against alcohol-induced necrosis and in preventing stress-induced ulcers in critically ill patients and new potential clinical applications for antacids are found. Expand
Acute damage of gastroduodenal mucosa by acetylsalicylic acid: no prolonged protection by antacids
TLDR
Protection by antacids against acetylsalacylic acid‐induced gastric mucosal lesions could not be documented at a time when intragastric pH presumably had returned to normal. Expand
Nitric oxide in gastroprotection by aluminium-containing antacids.
TLDR
Aluminium-containing antacids activate the NO system, which may contribute to the gastroprotective activity of these drugs through an increase in mucosal microcirculation. Expand
Role of intragastric pH in cytoprotection by antacids in rats.
TLDR
It is concluded that Maalox 70 and Al(OH)3 protect the gastric mucosa against ethanol damage but that this protection requires the presence of acid and may not depend entirely upon the mucosal production of PG. Expand
Gastroprotection by an aluminium- and magnesium hydroxide-containing antacid in rats. Role of endogenous prostanoids.
TLDR
It is postulate that mucosal prostanoids are not the primary mediators in the mechanism of their protective action on the gastric mucosa, and the gastroprotective activities of Maalox 70 against ethanol lesions cannot be reversed by pretreatment with indomethacin. Expand
Healing of chronic gastroduodenal ulcerations by antacids
TLDR
It was found that Maalox 70 and its active component, Al(OH)3, enhance significantly the healing of chronic gastric and duodenal ulcers observed during 7 and 14 days after their induction, suggesting that both factors may be involved in ulcer healing. Expand
Ulcer Healing Drugs and Endogenous Prostaglandins: Carbenoxolone, Antacids, Sucralfate, Bismuth, and H 2 -Receptor Antagonists
TLDR
It is reasonable to review the current knowledge on the role of endogenous prostaglandins in peptic ulcer therapy and potential mediators of acid-independent ulcer-healing effects are locally synthesized prostag landins. Expand
Gastric transmucosal potential difference: effect of antisecretory and gastroprotective drugs.
TLDR
The results indicate that the gastric barrier can be protected by various drugs that act through different mechanisms, and with the exception of ranitidine, all the drugs tested prevented the development of lesions after ethanol administration. Expand
Cytoprotective Drugs
TLDR
Antacid-afforded mucosal protection is entirely independent of the ability of antacids to neutralise luminal acid and, therefore, has all the features of cytoprotection. Expand
Activated aluminum complex derived from solubilized antacids exhibits enhanced cytoprotective activity in the rat.
TLDR
The data suggest that solubilization of aluminum-containing antacids in acidic medium enhances their mucosal protective activity, probably by releasing an activated species of aluminum ion reported to be a hexaaquoaluminum cation. Expand
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TLDR
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TLDR
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TLDR
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TLDR
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