Ant colony optimisation of decision trees for the detection of gene-gene interactions

  title={Ant colony optimisation of decision trees for the detection of gene-gene interactions},
  author={Emmanuel Sapin and Ed Keedwell and Timothy M. Frayling},
  journal={2014 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)},
In this paper ant colony optimisation is used to derive near-optimal interactions between a number of single nucleotide polymorphisms. This approach is used to discover small numbers of single nucleotide polymorphisms that are combined into a decision tree or contingency table model. It is shown that these two models can be highly discriminatory from a statistical perspective and a number of the single nucleotide polymorphisms discovered have been identified previously in large genome-wide… CONTINUE READING
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