Anr and its activation by PlcH activity in Pseudomonas aeruginosa host colonization and virulence.

@article{Jackson2013AnrAI,
  title={Anr and its activation by PlcH activity in Pseudomonas aeruginosa host colonization and virulence.},
  author={Angelyca A. Jackson and Maegan J. Gross and Emily F. Daniels and Thomas H. Hampton and J. H. Hammond and Isabelle Vallet-Gely and Simon L. B. Dove and Bruce A. Stanton and Deborah A. Hogan},
  journal={Journal of bacteriology},
  year={2013},
  volume={195 13},
  pages={
          3093-104
        }
}
Pseudomonas aeruginosa hemolytic phospholipase C (PlcH) degrades phosphatidylcholine (PC), an abundant lipid in cell membranes and lung surfactant. A ΔplcHR mutant, known to be defective in virulence in animal models, was less able to colonize epithelial cell monolayers and was defective in biofilm formation on plastic when grown in lung surfactant. Microarray analyses found that strains defective in PlcH production had lower levels of Anr-regulated transcripts than the wild type. PC… CONTINUE READING
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