Anoxic hepatocyte injury: role of reversible changes in elemental content and distribution.

@article{Berger1989AnoxicHI,
  title={Anoxic hepatocyte injury: role of reversible changes in elemental content and distribution.},
  author={M. L. Berger and Robert C. Reynolds and Herbert K. Hagler and Dennis J Bellotto and D. Parsons and K J Mulligan and L. M. Buja},
  journal={Hepatology},
  year={1989},
  volume={9 2},
  pages={219-28}
}
Examination of anoxic isolated hepatocytes by light and electron microscopy indicated that initial morphologic changes were largely localized to the periphery of the cells. This early phase consisted of surface bleb formation but was not accompanied by alterations in parameters of plasma membrane integrity (leakage of cellular enzymes, exclusion of trypan blue). The time course of changes in structure was temporally related to alterations in the elemental distribution and content of various… CONTINUE READING