Anoxia response in physiological potassium of the isolated inspiratory center in calibrated newborn rat brainstem slices.

@article{Ruangkittisakul2012AnoxiaRI,
  title={Anoxia response in physiological potassium of the isolated inspiratory center in calibrated newborn rat brainstem slices.},
  author={Araya Ruangkittisakul and Klaus Ballanyi},
  journal={Advances in experimental medicine and biology},
  year={2012},
  volume={758},
  pages={91-8}
}
Using newborn rat brainstem-spinal cords, we were the first to show that medullary inspiratory networks can generate the neonatal biphasic (initial acceleration-secondary slowing) respiratory response to severe hypoxia causing tissue anoxia. Our findings also indicated that medullary inspiratory interneurons remain functional during sustained anoxia due to effective utilization of anaerobic metabolism. In that previous work by us and related studies by others on respiratory anoxia responses in… CONTINUE READING

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