Anoxia-reoxygenation versus ischemia in isolated rat lungs.

  title={Anoxia-reoxygenation versus ischemia in isolated rat lungs.},
  author={Guochang Zhao and Abu B Al-mehdi and Aron B. Fisher},
  journal={The American journal of physiology},
  volume={273 6 Pt 1},
Oxidant generation in anoxia-reoxygenation and ischemia-reperfusion was compared in isolated rat lungs. Anoxia-reoxygenation was produced by N2 ventilation followed by O2 ventilation. After anoxia, lung ATP content was decreased by 59%. Oxygenated ischemia was produced by discontinuing perfusion while ventilation with O2 was maintained. With anoxia-reoxygenation, oxidant generation, evaluated by oxidation of dichlorodihydrofluorescein (H2DCF) to fluorescent dichlorofluorescein, increased 3.6… CONTINUE READING


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