Anoxia-reoxygenation versus ischemia in isolated rat lungs.

@article{Zhao1997AnoxiareoxygenationVI,
  title={Anoxia-reoxygenation versus ischemia in isolated rat lungs.},
  author={Guochang Zhao and Abu B Al-mehdi and Aron B. Fisher},
  journal={The American journal of physiology},
  year={1997},
  volume={273 6 Pt 1},
  pages={L1112-7}
}
Oxidant generation in anoxia-reoxygenation and ischemia-reperfusion was compared in isolated rat lungs. Anoxia-reoxygenation was produced by N2 ventilation followed by O2 ventilation. After anoxia, lung ATP content was decreased by 59%. Oxygenated ischemia was produced by discontinuing perfusion while ventilation with O2 was maintained. With anoxia-reoxygenation, oxidant generation, evaluated by oxidation of dichlorodihydrofluorescein (H2DCF) to fluorescent dichlorofluorescein, increased 3.6… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 31 extracted citations

Lung ischemia-reperfusion injury: a molecular and clinical view on a complex pathophysiological process.

American journal of physiology. Heart and circulatory physiology • 2010
View 20 Excerpts
Highly Influenced

Effect of NADPH oxidase inhibition on cardiopulmonary bypass-induced lung injury.

American journal of physiology. Heart and circulatory physiology • 2004
View 9 Excerpts
Highly Influenced

Pharmacology of Ischemia-Reperfusion. Translational Research Considerations.

Journal of investigative surgery : the official journal of the Academy of Surgical Research • 2016
View 3 Excerpts

Lung transplantation research: impact of a new surgical model.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery • 2012

References

Publications referenced by this paper.
Showing 1-10 of 32 references

Allopurinol dose is important for attenuation of liver dysfunction after normothermic ischemia: correlation between bile flow and liver enzymes in circulation.

Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie • 1994
View 1 Excerpt

Endothelial depolarization as an initiator of lung ischemic injury (Abstract)

A. Al-Mehdi, H. Shuman, A. B. Fisher
Am. J. Respir. Crit. Care Med • 1994
View 1 Excerpt

Similar Papers

Loading similar papers…