Anoxia on slow inward currents of immature hippocampal neurons.

  title={Anoxia on slow inward currents of immature hippocampal neurons.},
  author={Kre{\vs}imir Krnjevi{\'c} and Enrico Cherubini and Yehezkel Ben-Ari},
  journal={Journal of neurophysiology},
  volume={62 4},
1. The effects of brief anoxia (2-4 min) on membrane currents--especially the tetrodotoxin (TTX)-insensitive, Cd2+-sensitive slow inward currents, presumed to be Ca2+ currents--were studied by single-electrode voltage clamp in CA1 and CA3 neurons in submerged hippocampal slices from adult and newborn Wistar rats (PN1-13). 2. In mature neurons, anoxia had no effect on Q-type inward relaxations, but slowly activating C-type outward currents were depressed. The most striking change was the… CONTINUE READING