Anoxia inhibits guanosine salvage in cardiac myocytes

@article{Geisbuhler2004AnoxiaIG,
  title={Anoxia inhibits guanosine salvage in cardiac myocytes},
  author={T. Geisbuhler},
  journal={Basic Research in Cardiology},
  year={2004},
  volume={92},
  pages={359-367}
}
  • T. Geisbuhler
  • Published 2004
  • Biology, Medicine
  • Basic Research in Cardiology
The adult heart depends largely on salvage synthesis to supply its 5′-nucleotide needs. Previous work from this laboratory established that guanosine is metabolized into guanine 5′-nucleotides in heart cells, but that salvage rates are very slow as compared to adenosine. The author hypothesized that guanosine salvage is regulated according to the needs of the cell for guanine nucleotides. This hypothesis was tested using cardiac myocytes which were rendered anoxic for 0–60 min. During this… Expand
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