Anoxia-induced apoptosis occurs through a mitochondria-dependent pathway in lung epithelial cells.

@article{Santore2002AnoxiainducedAO,
  title={Anoxia-induced apoptosis occurs through a mitochondria-dependent pathway in lung epithelial cells.},
  author={Matthew T Santore and David S. McClintock and Vivian W-Y Lee and G. R. Scott Budinger and Navdeep S Chandel},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2002},
  volume={282 4},
  pages={L727-34}
}
The intracellular signaling pathways that control O(2) deprivation (anoxia)-induced apoptosis have not been fully defined in lung epithelial cells. We show here that the lung epithelial cell line A549 releases cytochrome c and activates caspase-9 followed by DNA fragmentation and plasma membrane breakage in response to anoxia. The antiapoptotic protein Bcl-X(L) prevented the anoxia-induced cell death by inhibiting the release of cytochrome c and caspase-9 activation. A549 cells devoid of… CONTINUE READING