Anoxia-induced NMDA receptor activation opens pannexin channels via Src family kinases.

  title={Anoxia-induced NMDA receptor activation opens pannexin channels via Src family kinases.},
  author={Nicholas L. Weilinger and Peter L Tang and Roger J Thompson},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={32 36},
Anoxic depolarization of pyramidal neurons results from a large inward current that is activated, in part, by excessive glutamate release during exposure to anoxia/ischemia. Pannexin-1 (Panx1) channels can be activated both by ischemia and NMDA receptors (NMDARs), but the mechanisms of Panx1 activation are unknown. We used whole-cell recordings to show that pharmacological inhibition or conditional genetic deletion of Panx1 strongly attenuates the anoxic depolarization of CA1 pyramidal neurons… CONTINUE READING
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Mechanisms of pannexin1 channel gating and regulation.

Biochimica et biophysica acta. Biomembranes • 2018
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