Anovulation in cyclooxygenase-2-deficient mice is restored by prostaglandin E2 and interleukin-1beta.

@article{Davis1999AnovulationIC,
  title={Anovulation in cyclooxygenase-2-deficient mice is restored by prostaglandin E2 and interleukin-1beta.},
  author={Barbara J. Davis and David E Lennard and Christopher A. Lee and Howard F. Tiano and Scott G. Morham and William C. Wetsel and Robert I Langenbach},
  journal={Endocrinology},
  year={1999},
  volume={140 6},
  pages={2685-95}
}
Mice carrying a null mutation for either of the two cyclooxygenase (COX) isoenzymes, necessary for prostanoid production, exhibit several isotype-specific reproductive abnormalities. Mice deficient in COX-1 are fertile but have decreased pup viability, whereas mice deficient in COX-2 fail to ovulate and have abnormal implantation and decidualization responses. The present study identifies the specific contribution of each COX isoenzyme in hypothalamic, pituitary, and ovarian function and… CONTINUE READING