Another discontinuous epitope on glycoprotein gp120 that is important in human immunodeficiency virus type 1 neutralization is identified by a monoclonal antibody.

@article{Ho1991AnotherDE,
  title={Another discontinuous epitope on glycoprotein gp120 that is important in human immunodeficiency virus type 1 neutralization is identified by a monoclonal antibody.},
  author={David D. Ho and Michael S. C. Fung and Yixiang Cao and Xiao-Ling Li and Changhui Sun and Tse Wen Chang and Nanxiong Sun},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1991},
  volume={88 20},
  pages={8949-52}
}
To define the domains in the envelope glycoprotein important for antibody neutralization of the human immunodeficiency virus type 1 (HIV-1), monoclonal antibodies (mAbs) were generated by immunizing mice with purified glycoprotein gp120 of the IIIB isolate. One mAb, G3-4, reacted with the gp120 of homologous (IIIB) and heterologous (RF) isolates. In addition, mAb G3-4 efficiently neutralized both IIIB and RF viruses in vitro, as well as four of nine primary HIV-1 isolates. In competition… CONTINUE READING

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