Anosmia: diagnosis and management

@article{Holbrook2003AnosmiaDA,
  title={Anosmia: diagnosis and management},
  author={Eric H. Holbrook and Donald A. Leopold},
  journal={Current Opinion in Otolaryngology \& Head and Neck Surgery},
  year={2003},
  volume={11},
  pages={54-60}
}
  • E. Holbrook, D. Leopold
  • Published 1 February 2003
  • Medicine
  • Current Opinion in Otolaryngology & Head and Neck Surgery
Disorders of the sense of smell can be frustrating for both the patient and physician. Ongoing research in this field has provided insight into the possible mechanisms for smell loss; however, therapy is still limited. Commercially distributed smell testing kits and newer screening tests using material available in all clinical settings have made diagnosis and measurement of the degree of impairment available to all physicians. A detailed history and physical examination are the most powerful… 
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References

SHOWING 1-10 OF 31 REFERENCES
Disorders of smell and taste.
Is Imaging Necessary in the Evaluation of the Patient with an Isolated Complaint of Anosmia?
  • N. Busaba
  • Medicine
    Ear, nose, & throat journal
  • 2001
TLDR
An investigation was conducted to assess the effectiveness of imaging studies in determining the etiology of olfactory loss in the patient with an isolated complaint of anosmia and no relevant findings on physical examination, including nasal endoscopy, found that these imaging studies did not add to the information obtained by the clinical history and endoscopic nasal examination.
The Diagnosis of a Conductive Olfactory Loss
TLDR
The purpose of this report is to characterize those aspects of the history and physical examination that will help to substantiate the diagnosis of a conductive olfactory loss.
University of pennsylvania smell identification test: A rapid quantitative olfactory function test for the clinic
TLDR
A clinically‐useful and reliable quantitative test of olfactory function is developed that can be self‐administered and uses microencapsulated odorants which are released by scratching standardized odor‐impregnated test booklets.
Rapid clinical evaluation of anosmia. The alcohol sniff test.
TLDR
The alcohol sniff test (AST), which uses the standard 70% isopropyl alcohol pad, was developed as a quick, reliable measure of olfactory function and should be incorporated in the routine cranial nerve examination.
Steroid‐Dependent Anosmia a
TLDR
Olfactory biopsy specimens taken during the course of evaluation and treatment show electron-optically normal olfactory receptors, meaning that the probable pathogenesis of the sensory deficit is an obstruction, mechanical and possibly biochemical.
The evaluation and management of olfactory disorder following upper respiratory tract infection.
  • S. Archer
  • Medicine
    Archives of otolaryngology--head & neck surgery
  • 2000
TLDR
Of 1834 patients who presented to 3 major centers of taste and smell disorders, 349 had smell dysfunction related to a URTI, and only 36% of these patients had anosmia on testing.
Olfaction and Its Alteration by Nasal Obstruction, Rhinitis, and Rhinosinusitis†
TLDR
Within the field of otorhinolaryngology, they have revealed that surgical and medical interventions in patients with rhinosinusitis do not, on average, lead to complete recovery of olfactory function, despite common beliefs to the contrary, and associations are generally lacking between measures of airway patency and olfFactory function in such cases.
Assessment of smell and taste in patients with allergic rhinitis.
TLDR
There was a positive influence of pharmacotherapy as well as specific desensitization and surgery on the impairment of the sense of smell in allergic rhinitis, and statistically positive correlations between the olfactory and gustatory thresholds were evaluated.
Candidate's Thesis: Chronic Sinusitis and Anosmia: Pathologic Changes in the Olfactory Mucosa
  • R. Kern
  • Medicine
    The Laryngoscope
  • 2000
Objectives To evaluate histological changes in the olfactory mucosa of patients with chronic rhinosinusitis. These results are analyzed in light of current understanding of the pathophysiology of
...
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