Anorexigenic effects of d-amphetamine and l-DOPA in the rat.

  title={Anorexigenic effects of d-amphetamine and l-DOPA in the rat.},
  author={Indravadan Sanghvi and George Singer and Eitan Friedman and Samuel Gershon},
  journal={Pharmacology, biochemistry, and behavior},
  volume={3 1},
The effect of amphetamine and l-dopa was compared in 22-hr food- and water-deprived rats. Amphetamine produced marked anorexia, and l-dopa significantly reduced food intake at 200 mg/kg. Following pretreatment with RO 4-4602, a decarboxylase inhibitor, 100 mg/kg of l-dopa, a dose that did not significantly affect eating, produced marked anorexia. The anorectic effect of both amphetamine and l-dopa was antagonized by propranolol, a beta adrenergic antagonist. Phentolamine, an alpha-adrenergic… CONTINUE READING