Corpus ID: 3469768

Anorexigenic effect of cholecystokinin is lost but that of CART (Cocaine and Amphetamine Regulated Transcript) peptide is preserved in monosodium glutamate obese mice.

@article{elezn2009AnorexigenicEO,
  title={Anorexigenic effect of cholecystokinin is lost but that of CART (Cocaine and Amphetamine Regulated Transcript) peptide is preserved in monosodium glutamate obese mice.},
  author={Blanka Železn{\'a} and Jana Maixnerov{\'a} and Resha Maty{\vs}kov{\'a} and Renata Haugvicov{\'a} and Darja Bloke{\vs}ov{\'a} and Lenka Malet{\'i}nsk{\'a}},
  journal={Physiological research},
  year={2009},
  volume={58 5},
  pages={
          717-23
        }
}
Monosodium glutamate (MSG) treatment of neonatal mice results in a selective damage to the arcuate nucleus (ARC) and development of obesity with increased adiposity at sustained body weight in the adulthood. Feeding pattern of the MSG obese mice is unusual. Our previous results showed that after 24-h fasting, MSG mice consumed negligible amount of food in several hours and therefore, it was impossible to register the effect of peptides attenuating food intake such as cholecystokinin (CCK) or… Expand
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TLDR
It is proposed that the obesity-related changes in the feeding behavior of the MSG-treated obese mice were the result of missing leptin and insulin receptors in ARC and consequent altered neuropeptide signaling, which makes the MSG model suitable for clarifying generally the central control of food intake. Expand
Reduced BAT function as a mechanism for obesity in the hypophagic, neuropeptide Y deficient monosodium glutamate-treated rat
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The early decrease in brown fat GLUT4 suggests an impairment of the hypothalamic sympathetic input to brown fat which disrupts thermogenesis, contributing to the development of adiposity in the presence of hypophagia. Expand
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TLDR
It is shown that CART (cocaine- and amphetamine-regulated transcript), a brain-located peptide, is a satiety factor and is closely associated with the actions of two important regulators of food intake, leptin and neuropeptide Y. Expand
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TLDR
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TLDR
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TLDR
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