Anorexia nervosa and osteoporosis

  title={Anorexia nervosa and osteoporosis},
  author={Madhusmita Misra and Anne Klibanski},
  journal={Reviews in Endocrine and Metabolic Disorders},
Anorexia nervosa (AN), a condition of severe undernutrition, is associated with low bone mineral density (BMD) in adults and adolescents. Whereas adult women with AN have an uncoupling of bone turnover markers with increased bone resorption and decreased bone formation markers, adolescents with AN have decreased bone turnover overall. Possible contributors to low BMD in AN include hypoestrogenism and hypoandrogenism, undernutrition with decreased lean body mass, and hypercortisolemia. IGF-I, a… CONTINUE READING
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