Anorexia nervosa and estrogen: Current status of the hypothesis

@article{Young2010AnorexiaNA,
  title={Anorexia nervosa and estrogen: Current status of the hypothesis},
  author={John K. Young},
  journal={Neuroscience \& Biobehavioral Reviews},
  year={2010},
  volume={34},
  pages={1195-1200}
}
  • John K. Young
  • Published 1 July 2010
  • Biology, Psychology, Medicine
  • Neuroscience & Biobehavioral Reviews
Anorexia nervosa and estrogen receptors.
Metabolic and neuroendocrine adaptations to undernutrition in anorexia nervosa: from a clinical to a basic research point of view
TLDR
Animal models that integrate either spontaneous genetic mutations or experimentally-induced food restriction with hyperactivity and/or social stress recapitulate the main metabolic and endocrine alterations of AN and provide mechanistic information between undernutrition state and symptoms of the disease.
Sex differences in the physiology of eating.
  • L. Asarian, N. Geary
  • Biology, Psychology
    American journal of physiology. Regulatory, integrative and comparative physiology
  • 2013
TLDR
The variety and physiological importance of what has been learned so far warrant intensifying basic, translational, and clinical research on sex differences in eating.
BDNF levels in adolescent patients with anorexia nervosa increase continuously to supranormal levels 2.5 years after first hospitalization
TLDR
Serum BDNF was only nominally lower at admission in patients with anorexia nervosa compared to healthy controls, but it increased continuously and reached supranormal levels at 2.5-year follow-up, which might represent a pre-existing trait or a consequence of the illness.
Brain Volume Loss, Astrocyte Reduction, and Inflammation in Anorexia Nervosa.
TLDR
Results point to important roles of the catabolic state and the very low gonadal steroid hormones in these patients and functional impairments could affect the role of astrocytes in supporting neurons metabolically, neurotransmitter reuptake, and synapse formation, among others.
Evidence for the role of EPHX2 gene variants in anorexia nervosa
TLDR
A novel association of gene variants within EPHX2 to susceptibility to AN is suggested and provides a foundation for future study of this important yet poorly understood condition.
Estrogen receptor 1 gene rs2295193 polymorphism and anorexia nervosa: New data and meta‐analysis
  • Chen Zhang, Jue Chen, Ze-ping Xiao
  • Biology, Psychology
    Asia-Pacific psychiatry : official journal of the Pacific Rim College of Psychiatrists
  • 2013
TLDR
A previous study indicated that the rs2295193 polymorphism in ESR1 may confer a genetic susceptibility to anorexia nervosa, and this work indicates that this polymorphism may be connected with this condition.
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References

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Estrogen and the etiology of anorexia nervosa
  • John K. Young
  • Psychology, Medicine
    Neuroscience & Biobehavioral Reviews
  • 1991
The Genetics of Anorexia Nervosa
TLDR
The purpose of this review is to discuss the different fields of genetic research—both in humans and animals—that have contributed to the understanding of this complex disorder.
A possible neuroendocrine basis of two clinical syndromes: Anorexia nervosa and the Kleine-Levin syndrome
TLDR
Two clinical syndromes, anorexia nervosa and the Kleine-Levin syndrome, are reviewed and a neuroendocrine basis for each is proposed and Hypothalamic hypersensitivity to sex steroids, arising from incomplete hypothalamic maturation during puberty, is postulated as a primary cause of the symptoms of both disorders.
Effect of anorexia nervosa on gonadotrophin secretion in a patient with gonadal dysgenesis
TLDR
The most remarkable observations concerned the gonadotrophin secretion: during the anorectic episode basal levels and peak responses to LRH and both LH and FSH were seen to decrease from the hypergonadotrophic range to the normal prepubertal range whereas after recovery from AN and regain of weight these rose back to castration levels.
Behavioral neuroendocrinology and treatment of anorexia nervosa
Testosterone Administration in Women With Anorexia Nervosa
TLDR
Low-dose T, administered transdermally, holds promise for promoting bone formation and lessening depression in women with AN, but the present findings must be confirmed in larger and longer-lasting randomized, placebo-controlled studies.
The genetics of anorexia nervosa.
TLDR
Evaluating critically the current state of research on molecular genetic studies of anorexia nervosa and providing guidance for future research is provided.
Association between an agouti-related protein gene polymorphism and anorexia nervosa
TLDR
The results implicate that antagonism of the MC4-r might be considered as pharmacotherapy for patients with AN, and indicate that variations of AGRP are associated with susceptibility for AN.
Testosterone administration in women with anorexia nervosa.
TLDR
Short-term low-dose testosterone may improve depressive symptoms and spatial cognition in women with AN and prevent decreased bone formation in AN, but because testosterone did not affect all markers of bone formation studied, further data are needed.
Anorectic estrogen mimics leptin's effect on the rewiring of melanocortin cells and Stat3 signaling in obese animals
TLDR
It is reported that estradiol (E2) triggers a robust increase in the number of excitatory inputs to POMC neurons in the arcuate nucleus of wild-type rats and mice, which supports the notion that synaptic plasticity of arcsuate nucleus feeding circuits is an inherent element in body weight regulation.
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