Anorexia induced by chronic central administration of cytokines at estimated pathophysiological concentrations.

@article{PlataSalamn1996AnorexiaIB,
  title={Anorexia induced by chronic central administration of cytokines at estimated pathophysiological concentrations.},
  author={Carlos Plata-Salam{\'a}n and G Sonti and J P Borkoski and Christine J. Wilson},
  journal={Physiology & behavior},
  year={1996},
  volume={60 3},
  pages={867-75}
}
Interleukin-1 beta (IL-1 beta), IL-6, IL-8, and tumor necrosis factor-alpha (TNF-alpha) induce acute anorexia by direct action in the central nervous system (CNS) at estimated pathophysiological concentrations reported in the cerebrospinal fluid (CSF). Cytokine-induced anorexia may also participate in the long-term anorexia observed during disease. Here, we studied the effects of chronic intracerebroventricular (ICV) microinfusion (through osmotic minipumps) of various cytokines on feeding and… CONTINUE READING

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