Anorexia in the elderly

@article{Morley1988AnorexiaIT,
  title={Anorexia in the elderly},
  author={John E. Morley and Andrew Jay Silver},
  journal={Neurobiology of Aging},
  year={1988},
  volume={9},
  pages={9-16}
}

The Anorexia of the Elderly

Animal studies have suggested that older rodents have an excessive satiety effect of cholecystokinin and a decreased opioid feeding drive, and in Alzheimer's disease, decreases in norepinephrine and neuropeptide Y may be involved in the anorexia seen in the patients.

Pathophysiology of anorexia.

  • J. Morley
  • Medicine
    Clinics in geriatric medicine
  • 2002

Pathophysiology of the anorexia of aging

  • J. Morley
  • Medicine, Biology
    Current opinion in clinical nutrition and metabolic care
  • 2013
The early recognition of anorexia of aging is important to allow intervention and prevent functional deterioration in older persons.

The anorexia of aging.

  • I. Chapman
  • Medicine
    Clinics in geriatric medicine
  • 2007

Anorexia in Older Persons

The physiological anorexia of aging is due to a decreased opioid (dynorphin) feeding drive and an increase in the satiating effect of the gastrointestinal hormone, cholecystokinin, which increases the propensity to develop pathologicalAnorexia when an older person develops either a medical or psychological illness.

Anorexia of Aging

Early recognition of anorexia, nutritional and pharmacological interventions can help prevent the development of malnutrition and poor clinical outcome in the elderly.

Anorexia and Aging

ABSTRACT Very little is known about anorexia among older adults. Since there is controversy and discussion about anorexia and aging, further research needs to be done. This article will discuss the

Anorexia: aetiology, epidemiology and management in older people.

Despite the changes in appetite regulation in older persons, the response to social and psychological stimulants in this age group is similar to that in younger adults, and pharmacological stimulants of appetite appear to be a promising intervention for anorexia.

Anorexia, body composition, and ageing

  • J. Morley
  • Medicine
    Current opinion in clinical nutrition and metabolic care
  • 2001
Over the lifespan there is a decline in food intake, including alterations in the gastrointestinal satiating system, the effect of elevated leptin levels, especially in men, and a variety of changes in central nervous system neurotransmitters.

The anorexia of ageing

Overall, the suppression of food intake was not different in the two age groups, but was increased in older women, suggesting reduced stimulation of feeding by endogenous opioids in this group, and raises the possibility of using CCK antagonists as stimulants of appetite and food intake in malnourished older people.
...

References

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Anorexia Nervosa in the Elderly

The following case report further illustrates the necessity to include anorexia nervosa in the differential diagnosis in patients over the age of 50.

Comparison of the Nutritional State of New and Long-term Patients in a Psychogeriatric Unit

The results indicated that psychogeriatric patients were at risk of experiencing nutritional deficiencies and those with senile dementia were likely to have more abnormalities than those with functional illnesses.

Tumor-induced anorexia in the Wistar rat.

Observations suggest that the LTW(m) tumor causes anorexia and that thisAnorexia is mediated by a circulating substance.

Neuropeptide regulation of appetite and weight.

The role of peptides as modulators of feeding behavior and weight regulation is focused on and peptides synthesized and released in the central nervous system and act as neurotransmitters are studied.

Neuropeptide Y increases food intake in mice.

In the studies reported here, intracerebroventricular administration of porcine NPY increased eating in mice and human NPY also increased food intake, whereas the free acid of NPY was inactive.

Elevated concentrations of CSF corticotropin-releasing factor-like immunoreactivity in depressed patients.

Findings are concordant with the hypothesis that CRF hypersecretion is, at least in part, responsible for the hyperactivity of the hypothalamo-pituitary-adrenal axis characteristic of major depression.

Age-related changes in central nervous system beta-endorphin and ACTH.

Age-related changes in brain and pituitary beta-endorphin and ACTH must be considered in the evaluation of the physiological aging process and when comparing studies of these neuropeptides.
...