Anorexia in rats caused by a valine-deficient diet is not ameliorated by systemic ghrelin treatment

@article{Goto2010AnorexiaIR,
  title={Anorexia in rats caused by a valine-deficient diet is not ameliorated by systemic ghrelin treatment},
  author={Sataro Goto and K. Nagao and Makoto Bannai and Masami Takahashi and Nobuyoshi Murakami},
  journal={Neuroscience},
  year={2010},
  volume={166},
  pages={333-340}
}
Rodents exhibit aversive behavior toward a diet that lacks at least one of the essential amino acids. We sought to determine whether the particular form of anorexia caused by such diets could be ameliorated by the administration of orexigenic peptides while simultaneously analyzing the neural mechanisms underlying anorexia. Rats were fed a valine-deficient diet, which induced severe anorexia (reducing food consumption by 80%). The severe anorexia was associated with a significant decrease in… CONTINUE READING
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