Anorexia following the intrahypothalamic administration of amylin.

  title={Anorexia following the intrahypothalamic administration of amylin.},
  author={William T. Chance and Ambikaipakan Balasubramaniam and Fu Suo Zhang and Sunil J. Wimalawansa and Josef E. Fischer},
  journal={Brain research},
  volume={539 2},
The intrahypothalamic injection of rat amylin reduced feeding in schedule-fed rats for eight hours. Specificity of this anorectic response was indicated by an appropriate dose-response relationship and the absence of effect of human amylin. Amylin-induced anorexia was accompanied by alterations in neurotransmitter metabolism similar to those observed in anorectic tumor-bearing rats. These results indicate that amylin may inhibit feeding by acting directly on hypothalamic neurons to alter… CONTINUE READING