Anorectic Drugs: Use in General Practice

  title={Anorectic Drugs: Use in General Practice},
  author={Denis Craddock},
SummaryThe treatment of obesity is one of the major measures available today in the field of preventive medicine. In particular, the coronary epidemic of Western civilisation would be halted, and most cases of maturity-onset diabetes prevented, if obesity were to be treated effectively.Anorectic drugs act mainly on the satiety centre in the hypothalamus to produce anorexia. They also have various metabolic effects involving fat and carbohydrate metabolism, but many of these may be secondary to… 
Phentermine therapy for obesity does not elevate blood pressure
The study data supports the authors’ conclusions that this formulation of phentermine is a safe and effective treatment adjunct for treating obesity, and it should be the first choice medicine when pharmacotherapy is considered for most obese patients.
Striatal Dopamine Homeostasis is Altered in Mice Following Roux-en-Y Gastric Bypass Surgery
Data demonstrate that RYGB surgery is associated with altered monoamine homeostasis at the level of the dorsal striatum, thus providing a critical foundation for future studies exploring central mechanisms of weight loss in RY GB.
Rate-dependent effects of monoamine releasers on intracranial self-stimulation in rats: implications for abuse liability assessment
The results extend the rate-dependent effects of monoamine releasers to behavior maintained under intracranial self-stimulation and suggest that the Y-intercept parameter of rate- dependency plots might be a useful metric of drug reward and predictor of drug self-administration measures of drug reinforcement.
Synthesis, molecular docking and in-vivo study of anti- hyperlipidemic activity in High fat Diet Animals for substituted morpholine derivatives
The present investigation involve synthesis of substituted morpholine derivative and its evaluation of in-vivo and in-silico molecular docking for determining the anti-hyperlipidemic activity proves that the synthesised morpholine compounds exhibit significance towards the anorectic activity.
Pharmacological Interventions for Obesity: Current and Future Targets
  • M. Bocarsly
  • Biology, Medicine
    Current Addiction Reports
  • 2018
Purpose of ReviewObesity in the USA has been on a constant rise since the Center for Disease Control and Prevention (CDC) began tracking it over 50 years ago. Despite focused attention on this


A Comparison of Mazindol (Teronac) with Diethylpropion in the Treatment of Exogenous Obesity
The number of side-effects was less in the mazindol group and mainly of an adrenergic, peripheral type, while those in the diethylpropion group are mainly of the central stimulant type.
Drugs of Dependence Though Not of Abuse: Fenfluramine and Imipramine
Measures of subjective feeling used by five patients indicated that depression of mood occurred about four days after fenfluramine withdrawal, and it is suggested that certain mood-influencing drugs may not be drugs of abuse because of some unpleasant initial effects, though they can be drugsof dependence.
Subjective effects of two anorexigenic agents fenfluramine and AN 448 in amphetamine-dependent subjects.
  • K. Götestam, L. Gunne
  • Psychology, Medicine
    The British journal of addiction to alcohol and other drugs
  • 1972
Summary Twenty-two amphetamine-dependent subjects, all imprisoned drug abusers, with a history of at least one year of intravenous abuse of central stimulants, were used for evaluation of the
Comparison of continuous and intermittent anorectic therapy in obesity.
Findings give firm support to Shearman's (1964) suggestion that the results of the gonadotrophin stimulation test would be more reliable than those of urinary gonadOTrophin determination as usually employed for clinical diagnostic purposes.
A long-acting appetite suppressant drug studied for 24 weeks in both continuous and sequential administration.
This trial evaluated the effect of both the continuous and intermittent administration of a long-acting appetite suppressant on weight loss, with special reference to side effects, since the drug was administered at 2 p.m. on each day.
A progressive resistance developed to the anorectic effects of AN 448 and fenfluramine so limiting their long‐term usefulness in the treatment of refractory obesity.
Toxic Psychosis Caused by “Preludin”
It is evident that the painless cardiac infarction is one of the causes of the not infrequent cases of heart failure of obscure aetiology found in the poor Asian patient.
Unusual effect of fenfluramine.
  • N. Imlah
  • Medicine
    British medical journal
  • 1970
The bleeding hypothesis would mean that protection against coronary thrombosis could be provided at very low cost and the blood transfusion service would cease to have any problem in acquiring blood.
[Drug treatment in psychiatry].
The preface to Fifth Edition Part I: General Principles states that psychoactive substance use and social and psychological aspects of drug treatment Part II: Clinical Applications, and the management of overdosage of centrally acting drugs, are general principles.