Anorectal malformations caused by defects in sonic hedgehog signaling.

  title={Anorectal malformations caused by defects in sonic hedgehog signaling.},
  author={Rong Qing Mo and Jin Hwan Kim and Jing Zhang and Chin Lee Chiang and Chi Chung Hui and Peter Chan Woo Kim},
  journal={The American journal of pathology},
  volume={159 2},
Anorectal malformations are a common clinical problem affecting the development of the distal hindgut in infants. The spectrum of anorectal malformations ranges from the mildly stenotic anus to imperforate anus with a fistula between the urinary and intestinal tracts to the most severe form, persistent cloaca. The etiology, embryology, and pathogenesis of anorectal malformations are poorly understood and controversial. Sonic hedgehog (Shh) is an endoderm-derived signaling molecule that induces… CONTINUE READING


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