Anopheles gambiae PGRPLC-Mediated Defense against Bacteria Modulates Infections with Malaria Parasites

@inproceedings{Meister2009AnophelesGP,
  title={Anopheles gambiae PGRPLC-Mediated Defense against Bacteria Modulates Infections with Malaria Parasites},
  author={Stephan Meister and Bogos Agianian and Fanny Turlure and Angela Rel{\'o}gio and Isabelle Morlais and Fotis C. Kafatos and George K. Christophides},
  booktitle={PLoS pathogens},
  year={2009}
}
Recognition of peptidoglycan (PGN) is paramount for insect antibacterial defenses. In the fruit fly Drosophila melanogaster, the transmembrane PGN Recognition Protein LC (PGRP-LC) is a receptor of the Imd signaling pathway that is activated after infection with bacteria, mainly Gram-negative (Gram-). Here we demonstrate that bacterial infections of the malaria mosquito Anopheles gambiae are sensed by the orthologous PGRPLC protein which then activates a signaling pathway that involves the Rel… CONTINUE READING

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View 4 Excerpts
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References

Publications referenced by this paper.
Showing 1-10 of 56 references

A splice variant of PGRPLC required for expression of antimicrobial peptides in Anopheles gambiae

H Lin, L Zhang, C Luna, NT Hoa, L Zheng
Insect Science • 2007
View 5 Excerpts
Highly Influenced

Structural basis for peptidoglycan binding by peptidoglycan recognition proteins.

Proceedings of the National Academy of Sciences of the United States of America • 2004
View 4 Excerpts
Highly Influenced

Infection-induced proteolysis of PGRP-LC controls the IMD activation and melanization cascades in Drosophila.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2008
View 1 Excerpt

Bacteria of the genus Asaia stably associate with Anopheles stephensi, an Asian malarial mosquito vector.

Proceedings of the National Academy of Sciences of the United States of America • 2007

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