Anomalies in ovary following oral exposure to oxytocin: mechanistic studies.

  title={Anomalies in ovary following oral exposure to oxytocin: mechanistic studies.},
  author={Manjari Mishra and Vivek K Mishra and B. Pal Chaudhuri and Vinay Kumar Khanna and Sanjay Mehrotra and Shakir Ali and Mukul Das},
  journal={Reproductive toxicology},
Ovarian anomalies following oral oxytocin (OT) (1 and 10 ng/100 μl) exposure of female Wistar rat pups (10-day old) for 25 days was undertaken as OT injections are illegally used for milk let down in cattle thereby causing oral exposure to human population from early age. OT exposure resulted in increased ovarian weight, γ globulin, total number of follicles, and number of corpus luteum (CLs); indicating higher ovulation. The mechanism may involve over-expression of pEGFR followed by downstream… 
The research study concluded that, synthetic OT altered sexual maturity as well as estrous cyclicity of mice at selected dose and duration; therefore a care must be taken for long term use.
Intestinal transepithelial permeability of oxytocin into the blood is dependent on the receptor for advanced glycation end products in mice
It is reported that plasma OT concentrations increased within 10 min after oral delivery in postnatal day 1–7 mice, and RAGE was abundant in the intestinal epithelial cells in both suckling pups and adults, suggesting that oral OT supplementation may be advantageous in OT drug development.
Analysis of oxytocin in milk samples and intake pattern in different age groups of Indian population
Since there is no prescribed level of OT in milk and the intake of OT through this commodity is quite high there is need to implement regulatory laws so that non-physiological OT exposure may not occur in children which may have deleterious effects.
Quantification of oxytocin residues in dairy milk from Sindh, Pakistan
The OT concentration was relatively higher in samples obtained from dairy farm, dairy shop and milk man than that in ultra-high temperature (UHT) and powder milk samples and there are no reports subjected to standardising a permissible OT level in dairy milk category.
Indel mutations within the bovine HSD17B3 gene are significantly associated with ovary morphological traits and mature follicle number
As a potential effective molecular marker loci significantly related to traits of ovary and follicle, these three indels could be used in practical molecular marker-assisted selection (MAS) breeding programs, to optimize female fertility and enhance economic efficiency in the dairy cow industry.
Neohormones in milk.
There are large gaps in knowledge and understanding of such lactocrine systems especially in regard to other neohormones, species, and neonatal organ systems.


Clomiphene citrate inhibits gonadotropin-induced ovulation by reducing cyclic adenosine 3',5'-cyclic monophosphate and prostaglandin E2 levels in rat ovary.
Clomiphene citrate inhibited gonadotropin-induced ovulation by reducing cAMP and PGE2 levels in the ovary, and E2 protected against these effects of CC on gonadotropic ovulation in rat.
Alteration of oestrous cycle length, ovarian function and oxytocin-induced release of prostaglandin F-2 alpha by intrauterine and intramuscular administration of recombinant bovine interferon-alpha to cows.
An experiment was conducted to (i) determine whether administration of recombinant bovine interferon-alpha I1 (rBoIFN-alpha) attenuates oxytocin-induced release of prostaglandin F-2 alpha and (ii)
Oxytocin facilitates female sexual maturation through a glia-to-neuron signaling pathway.
It is suggested that oxytocin facilitates female sexual development and that this effect is mediated by a mechanism involving glial production of PGE(2), which accelerates pulsatile GnRH release via P GE(2).
Effects of oxytocin administration on oxytocin release and milk ejection.
It seems that the reduction of spontaneous milk removal after chronic OT treatment was due to reduced contractibility of myoepithelial cells in the mammary gland at a physiological range of OT concentrations.
Expression and developmental regulation of oxytocin (OT) and oxytocin receptors (OTR) in the enteric nervous system (ENS) and intestinal epithelium
It is suggested that OT and OTR signaling might be important in ENS development and function and might play roles in visceral sensory perception and neural modulation of epithelial biology.
Enhanced Intestinal Absorption of Oxytocin Peptide Analogues in the Absence of Pancreatic Juice in Pigs
The results indicate that the increased absorption of peptides observed under conditions of diverted pancreatic juice cannot only be explained by the absence of pancreatic enzymes, but also by changed absorptive properties in the gastrointestinal tract.
Development of the Neonatal Rat Small Intestinal Barrier to Nonspecific Macromolecular Absorption. II. Role of Dietary Corticosterone
The results lend support to the view that C, a glucocorticoid known to be present in rat MM, may play a role in the normal ontogenetic closure of the small intestine to macromolecular absorption in the neonatal rat.
Are BMP-15 and GDF-9 primary determinants of ovulation quota in mammals?
Recent advances on the physiological, cellular and molecular roles of BMP-15 and GDF-9 are reviewed, which, potentially, link these oocyte-secreted factors to the species-specific determination of ovulation quota and litter size in mammals.
Concentrations and origin of oxytocin in breast milk.
Oxytocin is stable in milk and that oxytocin in maternal blood can be transferred to mik and then to neonates, and 3H-oxytocin was administered to lactating rats.
Primate Granulosa Cell Response via Prostaglandin E2 Receptors Increases Late in the Periovulatory Interval1
Granulosa cells respond to agonist stimulation of each of these receptors 36 h, but not 24 h, after hCG, supporting the hypothesis that granulosaCell response to PGE2 receptor agonists was examined 24 h and 36 h after h CG administration, when elevated P GE2 levels present in periovulatory follicles initiate ovulatory events.