Anomalies in ovary following oral exposure to oxytocin: mechanistic studies.

@article{Mishra2013AnomaliesIO,
  title={Anomalies in ovary following oral exposure to oxytocin: mechanistic studies.},
  author={Manjari Mishra and Vivek K Mishra and B. Pal Chaudhuri and Vinay Kumar Khanna and Sanjay Mehrotra and Shakir Ali and Mukul Das},
  journal={Reproductive toxicology},
  year={2013},
  volume={40},
  pages={
          24-34
        }
}
Ovarian anomalies following oral oxytocin (OT) (1 and 10 ng/100 μl) exposure of female Wistar rat pups (10-day old) for 25 days was undertaken as OT injections are illegally used for milk let down in cattle thereby causing oral exposure to human population from early age. OT exposure resulted in increased ovarian weight, γ globulin, total number of follicles, and number of corpus luteum (CLs); indicating higher ovulation. The mechanism may involve over-expression of pEGFR followed by downstream… 
ALTERATION OF RODENT ESTROUS CYCLE LENGTH FOLLOWING INTRAPERITONEAL ADMINISTRATION OF EXOGENOUS OXYTOCIN TO NEONATES
TLDR
The research study concluded that, synthetic OT altered sexual maturity as well as estrous cyclicity of mice at selected dose and duration; therefore a care must be taken for long term use.
Intestinal transepithelial permeability of oxytocin into the blood is dependent on the receptor for advanced glycation end products in mice
TLDR
It is reported that plasma OT concentrations increased within 10 min after oral delivery in postnatal day 1–7 mice, and RAGE was abundant in the intestinal epithelial cells in both suckling pups and adults, suggesting that oral OT supplementation may be advantageous in OT drug development.
Analysis of oxytocin in milk samples and intake pattern in different age groups of Indian population
TLDR
Since there is no prescribed level of OT in milk and the intake of OT through this commodity is quite high there is need to implement regulatory laws so that non-physiological OT exposure may not occur in children which may have deleterious effects.
Quantification of oxytocin residues in dairy milk from Sindh, Pakistan
TLDR
The OT concentration was relatively higher in samples obtained from dairy farm, dairy shop and milk man than that in ultra-high temperature (UHT) and powder milk samples and there are no reports subjected to standardising a permissible OT level in dairy milk category.
Indel mutations within the bovine HSD17B3 gene are significantly associated with ovary morphological traits and mature follicle number
TLDR
As a potential effective molecular marker loci significantly related to traits of ovary and follicle, these three indels could be used in practical molecular marker-assisted selection (MAS) breeding programs, to optimize female fertility and enhance economic efficiency in the dairy cow industry.
Neohormones in milk.
TLDR
There are large gaps in knowledge and understanding of such lactocrine systems especially in regard to other neohormones, species, and neonatal organ systems.

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