Anoikis: an emerging hallmark in health and diseases.

  title={Anoikis: an emerging hallmark in health and diseases.},
  author={Maria Letizia Taddei and Elisa Giannoni and Tania Fiaschi and Paola Chiarugi},
  journal={The Journal of pathology},
  volume={226 2},
Anoikis is a programmed cell death occurring upon cell detachment from the correct extracellular matrix, thus disrupting integrin ligation. It is a critical mechanism in preventing dysplastic cell growth or attachment to an inappropriate matrix. Anoikis prevents detached epithelial cells from colonizing elsewhere and is thus essential for tissue homeostasis and development. As anchorage-independent growth and epithelial-mesenchymal transition, two features associated with anoikis resistance… CONTINUE READING
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