Anoikis: a necessary death program for anchorage-dependent cells.

  title={Anoikis: a necessary death program for anchorage-dependent cells.},
  author={Paola Chiarugi and Elisa Giannoni},
  journal={Biochemical pharmacology},
  volume={76 11},
Cell to matrix adhesion is a key factor for cellular homeostasis and disruption of such interaction has adverse effects on cell survival. It leads to a specific type of apoptosis known as "anoikis" in most non-transformed cell types. This kind of apoptosis following loss of cell anchorage is important for development, tissue homeostasis and several diseases. Integrins sense mechanical forces arising from the matrix, thereby converting these stimuli to downstream signals modulating cell… CONTINUE READING
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