Anoikis, extracellular matrix, and apoptosis factors in isolated cell transplantation.

@article{Thomas1999AnoikisEM,
  title={Anoikis, extracellular matrix, and apoptosis factors in isolated cell transplantation.},
  author={Frank T Thomas and Juan Luis Contreras and Guadalupe Bilbao and Camillo Ricordi and David T. Curiel and Judith M. Thomas},
  journal={Surgery},
  year={1999},
  volume={126 2},
  pages={299-304}
}
BACKGROUND Isolated cell transplantation (ICT) of pancreatic islets (PI), nerve tissue, hepatocytes, and other cells is an exciting new concept of transplantation. PI transplantation can be successful in reversing diabetes but, unlike whole pancreas, grafts have a unique and unexplained high failure rate, with over 60% loss by 3 to 6 months. We established that PI of rhesus monkeys have a high rate of death within 48 hours of isolation as a result of apoptosis, as measured with the Annexin V… CONTINUE READING

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