Anogenital malignancies and pre‐malignancies

@article{Henquet2011AnogenitalMA,
  title={Anogenital malignancies and pre‐malignancies},
  author={Charles J. M. Henquet},
  journal={Journal of the European Academy of Dermatology and Venereology},
  year={2011},
  volume={25}
}
  • C. Henquet
  • Published 1 August 2011
  • Medicine
  • Journal of the European Academy of Dermatology and Venereology
Anogenital pre‐malignancies and malignancies are frequently encountered. Aetiopathogenetically, human papillomavirus (HPV) infection plays a critical role. However, there is a variable degree of association of HPV infection with the development of anogenital malignancies. In this context, the high level of clinically unapparent HPV infection should be considered. Therefore, the question arises if the association with HPV is always causative. Besides HPV, pre‐existent lichen sclerosus is also an… Expand
Anogenital malignancies and premalignancies: facts and controversies.
TLDR
The incidence of anal squamous cell carcinoma (SCC) has increased considerably in the past decade, mainly due to the growing number of cases in high-risk groups, such as men who have sex with men, immunosuppressed individuals, and patients with HIV infection. Expand
Understanding the Pathophysiology of Penile Cancer and Its Preneoplastic Lesions
TLDR
The epidemiology, risk factors, and pathophysiology of penile carcinoma are described here and human papillomavirus has been proven to play a pivotal role in a significant subset of cases. Expand
Lichen sclerosus and squamous cell carcinoma.
TLDR
The relationship between lichen sclerosus and squamous cell and verrucous carcinomas, the possible oncogenic mechanisms involved, and their possible association with HPV infection are considered. Expand
Premalignant Lesions of the Penis
TLDR
The current terminology and categorization of penile precursor lesions, including risk factors, management, and prevention, is reviewed in this chapter. Expand
Pathologic features of anogenital precancerous high‐grade squamous intraepithelial lesion (squamous cell carcinoma in situ)
Precancerous high‐grade squamous intraepithelial lesion (HSIL), the current consensus terminology for anogenital squamous cell carcinoma in situ (SCCIS), often presents with distinctiveExpand
Hpv-Associated Penile Pigmented Lesion
TLDR
A case of a 74-year-old man who was admitted to the University Hospital “Lozenetz” in connection with profuse variceal bleeding of the esophagus associated with liver cirrhosis of unknown etiology, confirmed the presence of HPV-associated giant condyloma of Buschke and Löwenstein in initial stage, without histopathological evidence for invasive and destructive tumor growth. Expand
Non-infectious inflammatory genital lesions.
TLDR
The genitalia may be the site of non-infectious inflammatory lesions that are generally manifested as balanoposthitis and vulvovaginitis, and consist of genital locations of general skin diseases, such as psoriasis,Lichen planus, lichen sclerosus, and other clinical entities with their own physiognomy,such as Zoon's balanitis-vulvitis. Expand
Bowenoid papulosis of genitalia responding to topical 5-Fluorouracil
TLDR
An adult male presenting with well defined, purplish papules of varying size with verrucous to smooth surface distributed discretely over medial side of the left thigh, scrotum, and penile shaft is described. Expand
Erythroplasia of Queyrat Treated with 5% Imiquimod Cream — Case Report Emphasizing the Role of Human Papilloma Virus Testing in a Clinical Setting
TLDR
Erythroplasia of Queyrat should be diagnosed in a non-compliant patient based on the clinical picture and HPV testing even in the absence of a biopsy, and aNon-surgical treatment should be initiated immediately. Expand
Oncogenic Human Papillomavirus Detection in Penile Lichen Sclerosus: An Update
TLDR
A retrospective analysis of paraffin-embedded penile biopsies obtained from adult patients with genital LS retrieved from institutional pathology files to better address a possible association of human papillomavirus (HPV) infection with penile lichen sclerosus (LS). Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 162 REFERENCES
Human papillomaviruses and genital disease.
TLDR
The authors detail the epidemiology, methods of transmission and risk factors, pathogenesis, and oncogenesis of HPV, and describe clinical manifestations and current treatments, and conclude with the latest information on prophylactic vaccine development and prospects for future control of HPV-related disease. Expand
Human papillomaviruses in the pathogenesis of anogenital cancer.
TLDR
Virus infection and viral gene expression emerge as necessary but obviously not sufficient factors for cancer induction, and "endogenous" modifications seem to be most important in the pathogenesis of premalignant lesions and tumor progression. Expand
Lichen sclerosus is frequently present in penile squamous cell carcinomas but is not always associated with oncogenic human papillomavirus
TLDR
Penile squamous cell carcinoma may occur on pre‐existing lesions of lichen sclerosus, but the prevalence of histological changes of LS in penile SCC is not well established and mucosal oncogenic human papillomaviruses (HPVs) are sometimes detected in penILE SCC, but have not been systematically sought. Expand
Review of squamous premalignant vulvar lesions.
TLDR
The history, epidemiology, aetiology, histology, clinical characteristics, treatment options, malignant potential and prevention strategies of the three squamous premalignant vulvar lesions are discussed. Expand
Review of squamous premalignant vulvar lesions.
TLDR
The history, epidemiology, aetiology, histology, clinical characteristics, treatment options, malignant potential and prevention strategies of the three squamous premalignant vulvar lesions are discussed. Expand
MALIGNANT PROGRESSION OF ANAL INTRA‐EPITHELIAL NEOPLASIA
TLDR
This study reviews the experience with AIN, reviewing the incidence and risk factors for development of invasive malignancy and the outcome of present management strategies. Expand
[Morphologic manifestations of human papillomavirus infection in the vulvar and anogenital region].
TLDR
The HPV infection of the vulva and anogenital region is reflected in a spectrum of histological changes, including typical, morphologically well-differentiated change is condyloma acuminatum, which is always an accompanying morphological quality in these changes. Expand
Cancers, precancers, and pseudocancers on the male genitalia. A review of clinical appearances, histopathology, and management.
  • G. Mikhail
  • Medicine
  • The Journal of dermatologic surgery and oncology
  • 1980
TLDR
Leukoplakia penis and balanitis xerotica obliterans are precancerous lesions, and Bowenoid papulosis is a new entity that is believed to be benign although it has histologic features of a carcinoma in situ. Expand
Human papillomavirus-associated tumors of the skin and mucosa.
TLDR
Novel therapeutic modalities for HPV tumors and prospects for prophylactic and therapeutic vaccination are presented and recent serologic findings based on enzyme-linked immunosorbent assay results with the use of viruslike particles are discussed. Expand
Papillomaviruses in the causation of human cancers — a brief historical account
TLDR
This review will cover some of the historical aspects of papillomavirus research; it tries briefly to analyze the present state of linking HPV to human cancers and will discuss some emerging developments. Expand
...
1
2
3
4
5
...