Anoctamin and transmembrane channel-like proteins are evolutionarily related.

@article{Hahn2009AnoctaminAT,
  title={Anoctamin and transmembrane channel-like proteins are evolutionarily related.},
  author={Yoonsoo Hahn and Dong Seon Kim and Ira Pastan and Byungkook Lee},
  journal={International journal of molecular medicine},
  year={2009},
  volume={24 1},
  pages={51-5}
}
The anoctamin (ANO) family of proteins, consisting of 10 members in mammals, are transmembrane proteins that have Ca2+-activated Cl- channel activity. The transmembrane channel-like (TMC) family of proteins, consisting of 8 members in mammals, are also transmembrane proteins of which mutations are implicated in various human conditions, such as hearing loss and epidermodysplasia verruciformis. Here we show that ANO and TMC proteins share high sequence similarity and probably the same membrane… CONTINUE READING

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