Anoctamin-1/TMEM16A is the major apical iodide channel of the thyrocyte.

  title={Anoctamin-1/TMEM16A is the major apical iodide channel of the thyrocyte.},
  author={Laure Twyffels and A Strickaert and Myrna Virreira and Claude Massart and Jacqueline van Sande and Corinne Wauquier and R. Beauwens and J. E. Dumont and Luis J. V. Galietta and Andrej Boom and V{\'e}ronique Kruys},
  journal={American journal of physiology. Cell physiology},
  volume={307 12},
Iodide is captured by thyrocytes through the Na(+)/I(-) symporter (NIS) before being released into the follicular lumen, where it is oxidized and incorporated into thyroglobulin for the production of thyroid hormones. Several reports point to pendrin as a candidate protein for iodide export from thyroid cells into the follicular lumen. Here, we show that a recently discovered Ca(2+)-activated anion channel, TMEM16A or anoctamin-1 (ANO1), also exports iodide from rat thyroid cell lines and from… CONTINUE READING
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