Annotation of a serum N-glycan library for rapid identification of structures.

@article{Aldredge2012AnnotationOA,
  title={Annotation of a serum N-glycan library for rapid identification of structures.},
  author={Danielle L Aldredge and Hyun Joo An and Ning Tang and Keith M. Waddell and Carlito B. Lebrilla},
  journal={Journal of proteome research},
  year={2012},
  volume={11 3},
  pages={
          1958-68
        }
}
Glycosylation is one of the most common post-translational modifications of proteins and has been shown to change with various pathological states including cancer. Global glycan profiling of human serum based on mass spectrometry has already led to several promising markers for diseases. The changes in glycan structure can result in altered monosaccharide composition as well as in the linkages between the monosaccharides. High-throughput glycan structural elucidation is not possible because of… CONTINUE READING

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