Annexin V imaging of acute doxorubicin cardiotoxicity (apoptosis) in rats.

  title={Annexin V imaging of acute doxorubicin cardiotoxicity (apoptosis) in rats.},
  author={Roelof J. Bennink and Maurice J B van den Hoff and Formijn J. van Hemert and Kora M. de Bruin and Astrid L Spijkerboer and J E Vanderheyden and Neil D Steinmetz and Berthe L. F. van Eck-Smit},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  volume={45 5},
UNLABELLED Anthracyclines are widely used in chemotherapy regimens for several malignancies, with cardiotoxicity being the major limiting factor in high-dose schedules. Recently, it was reported that doxorubicin induces apoptosis in cardiac muscle cells in vivo and, as such, is expected to be involved in the genesis of doxorubicin-induced cardiomyopathy. The aim of this study was to validate an animal model for in vivo monitoring of doxorubicin cardiotoxicity by means of scintigraphic detection… CONTINUE READING


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