Annexin V expression in apoptotic peripheral blood lymphocytes: An electron microscopic evaluation

@article{Cornelissen2002AnnexinVE,
  title={Annexin V expression in apoptotic peripheral blood lymphocytes: An electron microscopic evaluation},
  author={Maria Cornelissen and J. Philipp{\'e} and Stefan Sitter and Leo Isabelle De Ridder},
  journal={Apoptosis},
  year={2002},
  volume={7},
  pages={41-47}
}
Loss of plasma membrane asymmetry, resulting in the exposure of phosphatidylserine (PS), is considered to be an ‘early’ event in apoptosis. It is generally accepted to precede nuclear condensation, independent of the apoptosis inductive agent. In the present study we focus on 2 apoptotic parameters: PS exposure in comparison with morphological alterations. Peripheral blood lymphocytes were irradiated in vitro (5 Gy Co-γ-rays) or incubated with staurosporine (1 μM, 6 hours). PS exposure was… CONTINUE READING