Annexin V assay-proven anti-apoptotic effect of ascorbic acid 2-glucoside after cold ischemia/reperfusion injury in rat liver transplantation.

@article{Liu2003AnnexinVA,
  title={Annexin V assay-proven anti-apoptotic effect of ascorbic acid 2-glucoside after cold ischemia/reperfusion injury in rat liver transplantation.},
  author={J. Liu and T. Yagi and H. Sadamori and H. Matsukawa and Dongsheng Sun and N. Mitsuoka and M. Yamamura and J. Matsuoka and Z. Jin and I. Yamamoto and N. Tanaka},
  journal={Acta medica Okayama},
  year={2003},
  volume={57 5},
  pages={
          209-16
        }
}
Controversy exists over whether the predominant cell death of hepatocytes is due to apoptosis or necrosis after ischemia/reperfusion injury. In this study we investigated the predominant cell death of hepatocytes after cold ischemia/reperfusion injury using the Annexin V-based assay, and evaluated the anti-apoptotic effect of ascorbic acid 2-glucoside (AA-2G) added to the University of Wisconsin solution (UW solution) in rat liver transplantation. The retrieved liver was preserved in 4 UW… Expand
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