Annexin II/p11 is up-regulated in Purkinje cells in EAE and MS.

  title={Annexin II/p11 is up-regulated in Purkinje cells in EAE and MS.},
  author={Matthew J. Craner and Albert C. Lo and J Andrew Black and David Baker and Jia Newcombe and M. Louise Cuzner and Stephen G. Waxman},
  volume={14 4},
The sensory neuron specific sodium channel Na(v)1.8 is normally detectable at only very low levels within cerebellar Purkinje cells. Annexin II light chain (p11) binds to the amino terminus of Na(v)1.8 and facilitates its functional expression within the cell membrane. We previously demonstrated that expression of Na(v)1.8 is up-regulated in cerebellar Purkinje cells in experimental allergic encephalomyelitis (EAE) and multiple sclerosis (MS). In this study we demonstrate that expression of p11… CONTINUE READING


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