Annexin A7 gene is an important factor in the lymphatic metastasis of tumors.

@article{Jin2013AnnexinAG,
  title={Annexin A7 gene is an important factor in the lymphatic metastasis of tumors.},
  author={Yan-Ling Jin and Zhiqiang Wang and Hong Qu and Huan-Xi Wang and Mohammed Mohammed Ibrahim and Jun Zhang and Yu-hong Huang and Jun Wu and Lu-Lu Bai and Xian-yan Wang and Jiao Meng and Jianwu Tang},
  journal={Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie},
  year={2013},
  volume={67 4},
  pages={251-9}
}
In the tumor malignancy progression, lymph node metastasis (LNM) is recognized as an important factor. In this study, RNA interference (RNAi) was employed to down-regulate ANXA7 gene in Hca-F cells, a hepatocarcinoma cell line with high LNM rate. There was no significant effect on cell proliferation ability, but cell division, motility, and invasion abilities were markedly inhibited. By contrast, up-regulating the expression of ANXA7 gene in Hca-P cells with lower LNM rate, cell migration… CONTINUE READING

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