Annexin A6 stimulates the membrane recruitment of p120GAP to modulate Ras and Raf-1 activity

@article{Grewal2005AnnexinAS,
  title={Annexin A6 stimulates the membrane recruitment of p120GAP to modulate Ras and Raf-1 activity},
  author={Thomas Grewal and Rachael A Evans and Carles Rentero and Francesc Tebar and Laia Cubells and I{\~n}aki de Diego and Matthias F Kirchhoff and William E Hughes and Joerg Heeren and Kerry-Anne Rye and Franz Rinninger and Roger J Daly and Albert Pol and Carlos Enrich},
  journal={Oncogene},
  year={2005},
  volume={24},
  pages={5809-5820}
}
Annexin A6 is a calcium-dependent membrane-binding protein that interacts with signalling proteins, including the GTPase-activating protein p120GAP, one of the most important inactivators of Ras. Since we have demonstrated that annexin A6 inhibits EGF- and TPA-induced Ras signalling, we investigated whether modulation of Ras activity by annexin A6 was mediated via altered subcellular localization of p120GAP. First, we exploited our observation that high-density lipoproteins (HDL) can activate… CONTINUE READING

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