Annexin A6 inhibits Ras signalling in breast cancer cells

@article{Muga2009AnnexinAI,
  title={Annexin A6 inhibits Ras signalling in breast cancer cells},
  author={Silvia de Muga and Paul Timpson and Laia Cubells and Rachael A. Evans and Toni E Hayes and Carles Rentero and Anika Hegemann and Meritxell Reverter and Jasmin Leschner and Albert Pol and Francesc Tebar and Roger J. Daly and Carlos Enrich and Thomas Grewal},
  journal={Oncogene},
  year={2009},
  volume={28},
  pages={363-377}
}
Overexpression of epidermal growth factor receptor (EGFR) is associated with enhanced activation of wild-type (hyperactive) Ras in breast cancer. Little is known about the regulation of Ras inactivation and GTPase-activating proteins (GAPs), such as p120GAP, in cells with hyperactive Ras. Recently, we showed that in EGFR-overexpressing A431 cells, which lack endogenous Annexin A6 (AnxA6), ectopic expression of AnxA6 stimulates membrane recruitment of p120GAP to modulate Ras signalling. We now… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 41 CITATIONS

Role of annexin A 6 in cancer ( Review )

VIEW 8 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED

Annexin A6 and Late Endosomal Cholesterol Modulate Integrin Recycling and Cell Migration.

  • The Journal of biological chemistry
  • 2016
VIEW 4 EXCERPTS
CITES RESULTS & BACKGROUND

Annexin A6 is down-regulated through promoter methylation in gastric cancer.

  • American journal of translational research
  • 2013
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 67 REFERENCES

Molecular mechanisms involved in Ras inactivation: the annexin A6-p120GAP complex.

  • BioEssays : news and reviews in molecular, cellular and developmental biology
  • 2006
VIEW 9 EXCERPTS

Annexin A6 stimulates the membrane recruitment of p120GAP to modulate Ras and Raf-1 activity

Thomas Grewal, Rachael A Evans, +11 authors Carlos Enrich
  • Oncogene
  • 2005
VIEW 12 EXCERPTS
HIGHLY INFLUENTIAL

Single-molecule imaging analysis of Ras activation in living cells.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2004
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL