Annexin A6 contributes to the invasiveness of breast carcinoma cells by influencing the organization and localization of functional focal adhesions.

@article{Sakwe2011AnnexinAC,
  title={Annexin A6 contributes to the invasiveness of breast carcinoma cells by influencing the organization and localization of functional focal adhesions.},
  author={Amos Sakwe and Rainelli B. Koumangoye and Bobby Guillory and Josiah Ochieng},
  journal={Experimental cell research},
  year={2011},
  volume={317 6},
  pages={
          823-37
        }
}
The interaction of annexin A6 (AnxA6) with membrane phospholipids and either specific extracellular matrix (ECM) components or F-actin suggests that it may influence cellular processes associated with rapid plasma membrane reorganization such as cell adhesion and motility. Here, we examined the putative roles of AnxA6 in adhesion-related cellular processes that contribute to breast cancer progression. We show that breast cancer cells secrete annexins via the exosomal pathway and that the… CONTINUE READING
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