Annexin A6 and Late Endosomal Cholesterol Modulate Integrin Recycling and Cell Migration.

@article{GarcaMelero2016AnnexinAA,
  title={Annexin A6 and Late Endosomal Cholesterol Modulate Integrin Recycling and Cell Migration.},
  author={Ana Garc{\'i}a-Melero and Meritxell Reverter and Monira Hoque and Elsa Meneses-Salas and Meryem Koese and James R. W. Conway and Camilla H Johnsen and Anna {\'A}lvarez-Guaita and Frederic Morales-Paytuvi and Yasmin A Elmaghrabi and Albert Pol and Francesc Tebar and Rachael Z Murray and Paul Timpson and Carlos Enrich and Thomas Grewal and Carles Rentero},
  journal={The Journal of biological chemistry},
  year={2016},
  volume={291 3},
  pages={1320-35}
}
Annexins are a family of proteins that bind to phospholipids in a calcium-dependent manner. Earlier studies implicated annexin A6 (AnxA6) to inhibit secretion and participate in the organization of the extracellular matrix. We recently showed that elevated AnxA6 levels significantly reduced secretion of the extracellular matrix protein fibronectin (FN). Because FN is directly linked to the ability of cells to migrate, this prompted us to investigate the role of AnxA6 in cell migration. Up… CONTINUE READING