Annexin A3 is associated with cell death in lactacystin-mediated neuronal injury.

@article{Chong2010AnnexinAI,
  title={Annexin A3 is associated with cell death in lactacystin-mediated neuronal injury.},
  author={Kevin Wai Yin Chong and Minghui Jessica Chen and Evelyn Siew-Chuan Koay and Boon Seng Wong and Alan Lee and Françoise Russo-Marie and Nam Sang Cheung},
  journal={Neuroscience letters},
  year={2010},
  volume={485 2},
  pages={129-33}
}
Massive neuronal apoptosis and accumulation of protein aggregates in the cortex and hippocampus of the brain are hallmarks of several neurodegenerative disorders, indicating ubiquitin proteasome system (UPS) dysfunction. Lactacystin, a classical proteasome inhibitor, is used to simulate ubiquitin proteasome system dysfunction in neurons to mimic pathological features of neurodegenerative disorders. Based on Western blot analyses, we reported for the first time that annexin A3 (AnxA3) is not… CONTINUE READING