Annexin A2 regulates β1 integrin internalization and intestinal epithelial cell migration.

@article{Rankin2013AnnexinAR,
  title={Annexin A2 regulates β1 integrin internalization and intestinal epithelial cell migration.},
  author={Carl Robert Rankin and Roland S. Hilgarth and Giovanna Leoni and Mike Kwon and Kyle A Den Beste and Charles A Parkos and Asma Nusrat},
  journal={The Journal of biological chemistry},
  year={2013},
  volume={288 21},
  pages={
          15229-39
        }
}
The gastrointestinal epithelium functions as an important barrier that separates luminal contents from the underlying tissue compartment and is vital in maintaining mucosal homeostasis. Mucosal wounds in inflammatory disorders compromise the critical epithelial barrier. In response to injury, intestinal epithelial cells (IECs) rapidly migrate to reseal wounds. We have previously observed that a membrane-associated, actin binding protein, annexin A2 (AnxA2), is up-regulated in migrating IECs and… CONTINUE READING

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