Annexin A2 is a soluble mediator of macrophage activation.

@article{Swisher2007AnnexinAI,
  title={Annexin A2 is a soluble mediator of macrophage activation.},
  author={Jennifer F A Swisher and Utsha Khatri and Gerald M Feldman},
  journal={Journal of leukocyte biology},
  year={2007},
  volume={82 5},
  pages={
          1174-84
        }
}
On the surface of the macrophage, annexin A2 tetramer (A2t) serves as a docking protein or recognition element for bacterial and viral pathogens. Plasma levels of free A2t have been reported to increase following infection, although the mechanistic significance of this observation is unclear. Although annexin A2 had generally been thought to play an anti-inflammatory role, soluble A2t stimulates MAP kinase activity in bone marrow stromal cells downstream of a recently cloned receptor. This… CONTINUE READING

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